262587

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4160722..4161341 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OI501_RS20695 Protein ID WP_002892050.1
Coordinates 4161123..4161341 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OI501_RS20690 Protein ID WP_002892066.1
Coordinates 4160722..4161096 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS20680 (OI501_20685) 4155874..4157067 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OI501_RS20685 (OI501_20690) 4157090..4160236 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OI501_RS20690 (OI501_20695) 4160722..4161096 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OI501_RS20695 (OI501_20700) 4161123..4161341 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OI501_RS20700 (OI501_20705) 4161500..4162066 + 567 WP_002892030.1 maltose O-acetyltransferase -
OI501_RS20705 (OI501_20710) 4162038..4162178 - 141 WP_004147370.1 hypothetical protein -
OI501_RS20710 (OI501_20715) 4162199..4162669 + 471 WP_002892026.1 YlaC family protein -
OI501_RS20715 (OI501_20720) 4162644..4164095 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OI501_RS20720 (OI501_20725) 4164196..4164894 + 699 WP_002892021.1 GNAT family protein -
OI501_RS20725 (OI501_20730) 4164891..4165031 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OI501_RS20730 (OI501_20735) 4165031..4165294 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T262587 WP_002892050.1 NZ_CP109973:4161123-4161341 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT262587 WP_002892066.1 NZ_CP109973:4160722-4161096 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References