262586

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3339153..3339784 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name hicA Uniprot ID A0A1Q8YTV3
Locus tag OI501_RS16755 Protein ID WP_012542177.1
Coordinates 3339608..3339784 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3Q9U6R4
Locus tag OI501_RS16750 Protein ID WP_017898984.1
Coordinates 3339153..3339560 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS16715 (OI501_16720) 3334517..3334951 - 435 WP_012542168.1 phage terminase small subunit P27 family -
OI501_RS16720 (OI501_16725) 3335199..3335630 - 432 WP_023279521.1 hypothetical protein -
OI501_RS16725 (OI501_16730) 3335627..3335944 - 318 WP_023279522.1 hypothetical protein -
OI501_RS16730 (OI501_16735) 3335896..3336258 - 363 WP_014228901.1 HNH endonuclease -
OI501_RS16735 (OI501_16740) 3337383..3337733 - 351 WP_017898986.1 hypothetical protein -
OI501_RS16740 (OI501_16745) 3337730..3338227 - 498 WP_023279523.1 lysozyme -
OI501_RS16745 (OI501_16750) 3338227..3338442 - 216 WP_017880269.1 class II holin family protein -
OI501_RS16750 (OI501_16755) 3339153..3339560 - 408 WP_017898984.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OI501_RS16755 (OI501_16760) 3339608..3339784 - 177 WP_012542177.1 type II toxin-antitoxin system HicA family toxin Toxin
OI501_RS16760 (OI501_16765) 3340148..3341932 + 1785 WP_032415155.1 ATP-binding protein -
OI501_RS16765 (OI501_16770) 3341952..3342986 + 1035 WP_219071718.1 DNA cytosine methyltransferase -
OI501_RS16770 (OI501_16775) 3343011..3343352 - 342 WP_017898982.1 antiterminator Q family protein -
OI501_RS16775 (OI501_16780) 3343365..3344396 - 1032 WP_071058942.1 DUF968 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3305684..3363195 57511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6632.83 Da        Isoelectric Point: 11.0174

>T262586 WP_012542177.1 NZ_CP109973:c3339784-3339608 [Klebsiella pneumoniae]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK

Download         Length: 177 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14959.96 Da        Isoelectric Point: 4.4277

>AT262586 WP_017898984.1 NZ_CP109973:c3339560-3339153 [Klebsiella pneumoniae]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARLINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8YTV3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9U6R4

References