262585

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2744788..2746376 Replicon chromosome
Accession NZ_CP109973
Organism Klebsiella pneumoniae strain 857

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OI501_RS13640 Protein ID WP_004199851.1
Coordinates 2744788..2746110 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OI501_RS13645 Protein ID WP_002904790.1
Coordinates 2746110..2746376 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI501_RS13625 (OI501_13630) 2739853..2742354 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
OI501_RS13630 (OI501_13635) 2742342..2743346 + 1005 WP_004199852.1 fimbrial protein -
OI501_RS13635 (OI501_13640) 2743479..2744771 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OI501_RS13640 (OI501_13645) 2744788..2746110 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OI501_RS13645 (OI501_13650) 2746110..2746376 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OI501_RS13650 (OI501_13655) 2746642..2746968 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OI501_RS13655 (OI501_13660) 2746965..2747465 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OI501_RS13660 (OI501_13665) 2747443..2748822 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
OI501_RS13665 (OI501_13670) 2749168..2750322 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OI501_RS13670 (OI501_13675) 2750303..2751226 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T262585 WP_004199851.1 NZ_CP109973:c2746110-2744788 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT262585 WP_002904790.1 NZ_CP109973:c2746376-2746110 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References