Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 580286..580911 Replicon chromosome
Accession NZ_CP109968
Organism Agrobacterium salinitolerans strain CFBP5507

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CFBP5507_RS02825 Protein ID WP_137409966.1
Coordinates 580552..580911 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A420FBH4
Locus tag CFBP5507_RS02820 Protein ID WP_059753836.1
Coordinates 580286..580552 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5507_RS02800 (CFBP5507_02800) 575762..576586 + 825 WP_137410972.1 class D beta-lactamase -
CFBP5507_RS02805 (CFBP5507_02805) 576963..579545 + 2583 WP_170985460.1 heavy metal translocating P-type ATPase -
CFBP5507_RS02810 (CFBP5507_02810) 579542..579964 + 423 WP_137409965.1 Cu(I)-responsive transcriptional regulator -
CFBP5507_RS02815 (CFBP5507_02815) 580017..580217 + 201 WP_080791105.1 heavy-metal-associated domain-containing protein -
CFBP5507_RS02820 (CFBP5507_02820) 580286..580552 + 267 WP_059753836.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CFBP5507_RS02825 (CFBP5507_02825) 580552..580911 + 360 WP_137409966.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CFBP5507_RS02830 (CFBP5507_02830) 580932..581180 - 249 WP_077982678.1 hypothetical protein -
CFBP5507_RS02835 (CFBP5507_02835) 581358..582746 + 1389 WP_170985565.1 MFS transporter -
CFBP5507_RS02840 (CFBP5507_02840) 582822..582995 - 174 WP_077982677.1 hypothetical protein -
CFBP5507_RS02845 (CFBP5507_02845) 583064..584779 - 1716 WP_137409968.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12910.10 Da        Isoelectric Point: 9.2810

>T262575 WP_137409966.1 NZ_CP109968:580552-580911 [Agrobacterium salinitolerans]
MVRSQVPKRGDVYLVDLNPVIGSEIRDEHRCIVITPREINAVGLCLVVPVNTGGLFTRRAGLAVNISGHKTTGVALCNQV
RSMDIVARASQKKAKYIETLDDATIDKIVGRVISMIDPA

Download         Length: 360 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9424.90 Da        Isoelectric Point: 4.5983

>AT262575 WP_059753836.1 NZ_CP109968:580286-580552 [Agrobacterium salinitolerans]
MTVTTRIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRQEKKRFTLAELLEGADEVAALNASAREWDEA
PPVGKEAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A420FBH4

References