Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4774476..4776157 Replicon chromosome
Accession NZ_CP109963
Organism Klebsiella pneumoniae isolate NY13307

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OJ970_RS23550 Protein ID WP_002885155.1
Coordinates 4774476..4775393 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag OJ970_RS23555 Protein ID WP_004151732.1
Coordinates 4775399..4776157 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ970_RS23530 (OJ970_23535) 4769782..4771302 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OJ970_RS23535 (OJ970_23540) 4771299..4772297 + 999 WP_002885172.1 ribose ABC transporter permease -
OJ970_RS23540 (OJ970_23545) 4772328..4773269 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OJ970_RS23545 (OJ970_23550) 4773344..4774351 + 1008 WP_004151731.1 carbohydrate kinase family protein -
OJ970_RS23550 (OJ970_23555) 4774476..4775393 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OJ970_RS23555 (OJ970_23560) 4775399..4776157 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OJ970_RS23560 (OJ970_23565) 4776243..4776971 - 729 WP_002885152.1 response regulator transcription factor -
OJ970_RS23565 (OJ970_23570) 4777244..4779391 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
OJ970_RS23570 (OJ970_23575) 4779621..4780307 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T262563 WP_002885155.1 NZ_CP109963:c4775393-4774476 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT262563 WP_004151732.1 NZ_CP109963:c4776157-4775399 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References