Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4618292..4618808 Replicon chromosome
Accession NZ_CP109963
Organism Klebsiella pneumoniae isolate NY13307

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OJ970_RS22750 Protein ID WP_002886902.1
Coordinates 4618292..4618576 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OJ970_RS22755 Protein ID WP_002886901.1
Coordinates 4618566..4618808 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ970_RS22725 (OJ970_22730) 4613776..4614084 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OJ970_RS22730 (OJ970_22735) 4614169..4614342 + 174 WP_002886906.1 hypothetical protein -
OJ970_RS22735 (OJ970_22740) 4614345..4615088 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OJ970_RS22740 (OJ970_22745) 4615445..4617583 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OJ970_RS22745 (OJ970_22750) 4617824..4618288 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OJ970_RS22750 (OJ970_22755) 4618292..4618576 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ970_RS22755 (OJ970_22760) 4618566..4618808 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OJ970_RS22760 (OJ970_22765) 4618886..4620796 - 1911 WP_004152270.1 PRD domain-containing protein -
OJ970_RS22765 (OJ970_22770) 4620819..4621973 - 1155 WP_002886900.1 lactonase family protein -
OJ970_RS22770 (OJ970_22775) 4622039..4622779 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T262562 WP_002886902.1 NZ_CP109963:c4618576-4618292 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT262562 WP_002886901.1 NZ_CP109963:c4618808-4618566 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References