Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 882020..882677 Replicon chromosome
Accession NZ_CP109963
Organism Klebsiella pneumoniae isolate NY13307

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OJ970_RS04450 Protein ID WP_002916310.1
Coordinates 882267..882677 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OJ970_RS04445 Protein ID WP_002916312.1
Coordinates 882020..882286 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ970_RS04420 (OJ970_04420) 877176..878609 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OJ970_RS04425 (OJ970_04425) 878728..879456 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OJ970_RS04430 (OJ970_04430) 879506..879817 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OJ970_RS04435 (OJ970_04435) 879981..880640 + 660 WP_002916317.1 hemolysin III family protein -
OJ970_RS04440 (OJ970_04440) 880791..881774 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OJ970_RS04445 (OJ970_04445) 882020..882286 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OJ970_RS04450 (OJ970_04450) 882267..882677 + 411 WP_002916310.1 protein YgfX Toxin
OJ970_RS04455 (OJ970_04455) 882684..883205 - 522 WP_002916308.1 flavodoxin FldB -
OJ970_RS04460 (OJ970_04460) 883306..884202 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OJ970_RS04465 (OJ970_04465) 884225..884938 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OJ970_RS04470 (OJ970_04470) 884944..886677 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T262554 WP_002916310.1 NZ_CP109963:882267-882677 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT262554 WP_002916312.1 NZ_CP109963:882020-882286 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References