Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 745482..746257 Replicon chromosome
Accession NZ_CP109963
Organism Klebsiella pneumoniae isolate NY13307

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OJ970_RS03720 Protein ID WP_004150910.1
Coordinates 745772..746257 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OJ970_RS03715 Protein ID WP_004150912.1
Coordinates 745482..745775 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ970_RS03695 (OJ970_03695) 740690..741292 - 603 WP_002916735.1 short chain dehydrogenase -
OJ970_RS03700 (OJ970_03700) 741390..742301 + 912 WP_004188550.1 LysR family transcriptional regulator -
OJ970_RS03705 (OJ970_03705) 742302..743450 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OJ970_RS03710 (OJ970_03710) 743461..744837 - 1377 WP_004217775.1 cystathionine beta-synthase -
OJ970_RS03715 (OJ970_03715) 745482..745775 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OJ970_RS03720 (OJ970_03720) 745772..746257 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OJ970_RS03725 (OJ970_03725) 746776..747756 + 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
OJ970_RS03730 (OJ970_03730) 748161..748754 + 594 WP_004188553.1 hypothetical protein -
OJ970_RS03735 (OJ970_03735) 748851..749067 + 217 Protein_734 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T262553 WP_004150910.1 NZ_CP109963:745772-746257 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT262553 WP_004150912.1 NZ_CP109963:745482-745775 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References