Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3886990..3887576 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag OI124_RS18735 Protein ID WP_042014162.1
Coordinates 3886990..3887220 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag OI124_RS18740 Protein ID WP_000593555.1
Coordinates 3887217..3887576 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS18725 (3883027) 3883027..3885762 + 2736 WP_228569535.1 ribosome-associated ATPase/putative transporter RbbA -
OI124_RS18730 (3885762) 3885762..3886886 + 1125 WP_001314210.1 ABC transporter permease -
OI124_RS18735 (3886990) 3886990..3887220 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
OI124_RS18740 (3887217) 3887217..3887576 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OI124_RS18745 (3887696) 3887696..3888097 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
OI124_RS18750 (3888103) 3888103..3888909 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
OI124_RS18755 (3888906) 3888906..3889670 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
OI124_RS18760 (3889670) 3889670..3890503 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
OI124_RS18765 (3890500) 3890500..3891444 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T262530 WP_042014162.1 NZ_CP109953:3886990-3887220 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT262530 WP_000593555.1 NZ_CP109953:3887217-3887576 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References