Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1305587..1306398 Replicon chromosome
Accession NC_017094
Organism Leptospirillum ferrooxidans C2-3

Toxin (Protein)


Gene name TacT3 Uniprot ID I0INX2
Locus tag LFE_RS06635 Protein ID WP_014449460.1
Coordinates 1305862..1306398 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID I0INX1
Locus tag LFE_RS06630 Protein ID WP_014449459.1
Coordinates 1305587..1305865 (+) Length 93 a.a.

Genomic Context

LFE_RS06630LFE_RS06635LFE_RS13920LFE_RS13925LFE_RS06675LFE_RS06615LFE_RS06620LFE_RS06625LFE_RS13670LFE_RS06640LFE_RS14120LFE_RS06660LFE_RS06670
Location: 1305587..1305865 (279 bp)
Type: Antitoxin
Protein ID: WP_014449459.1
Location: 1305862..1306398 (537 bp)
Type: Toxin
Protein ID: WP_014449460.1
Location: 1307388..1307687 (300 bp)
Type: Others
Protein ID: WP_014449464.1
Location: 1307803..1308003 (201 bp)
Type: Others
Protein ID: WP_014449466.1
Location: 1310295..1311365 (1071 bp)
Type: Others
Protein ID: WP_014449470.1
Location: 1302290..1303519 (1230 bp)
Type: Others
Protein ID: WP_148272715.1
Location: 1303539..1304966 (1428 bp)
Type: Others
Protein ID: WP_014449458.1
Location: 1305027..1305509 (483 bp)
Type: Others
Protein ID: WP_148272577.1
Location: 1306328..1306636 (309 bp)
Type: Others
Protein ID: WP_081495368.1
Location: 1306633..1306863 (231 bp)
Type: Others
Protein ID: WP_014449462.1
Location: 1306958..1307245 (288 bp)
Type: Others
Protein ID: WP_014449463.1
Location: 1308176..1308793 (618 bp)
Type: Others
Protein ID: WP_041774880.1
Location: 1309542..1310150 (609 bp)
Type: Others
Protein ID: WP_014449469.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFE_RS066151302290..1303519-1230WP_148272715.1efflux RND transporter periplasmic adaptor subunit-
LFE_RS066201303539..1304966-1428WP_014449458.1TolC family protein-
LFE_RS066251305027..1305509-483WP_148272577.1hypothetical protein-
LFE_RS066301305587..1305865+279WP_014449459.1DUF1778 domain-containing proteinAntitoxin
LFE_RS066351305862..1306398+537WP_014449460.1GNAT family N-acetyltransferaseToxin
LFE_RS136701306328..1306636-309WP_081495368.1DUF5615 family PIN-like protein-
LFE_RS066401306633..1306863-231WP_014449462.1DUF433 domain-containing protein-
LFE_RS141201306958..1307245-288WP_014449463.1hypothetical protein-
LFE_RS139201307388..1307687+300WP_014449464.1hypothetical protein-
LFE_RS139251307803..1308003+201WP_014449466.1hypothetical protein-
LFE_RS066601308176..1308793-618WP_041774880.1YqhA family protein-
LFE_RS066701309542..1310150-609WP_014449469.1hypothetical protein-
LFE_RS066751310295..1311365+1071WP_014449470.1transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-88)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19236.83 Da        Isoelectric Point: 8.3056

>T26253 WP_014449460.1 NC_017094:1305862-1306398 [Leptospirillum ferrooxidans C2-3]
MTFPAWHEEPVSKKHDRKSFDCGDAELNDFLHRHARQSHDLGGAKTFLAIDNDDNKTILGFYSLAPGAVLYADTPQTFRR
GLAPHDVPGFRLARIATHVCVHGQGLGGQLLASAARRCLLAAAEAGGVLLIIDTKNDRAAKWYASYGAVPLNNRSLTLVM
SLATFAAELKAADQSRPG

Download         Length: 537 bp

>T26253 NC_017094:1305862-1306398 [Leptospirillum ferrooxidans C2-3]
TTGACGTTTCCGGCCTGGCACGAAGAGCCGGTTTCCAAGAAGCATGATCGCAAATCGTTCGATTGCGGCGATGCGGAGCT
AAACGATTTTCTGCATCGTCATGCACGTCAAAGCCATGACCTTGGCGGCGCAAAAACCTTCCTGGCTATCGACAACGACG
ATAACAAAACGATCCTCGGCTTCTACAGCTTGGCGCCGGGCGCGGTCTTGTATGCAGATACGCCGCAGACTTTTCGTCGC
GGCCTTGCACCGCACGATGTTCCGGGGTTCCGTCTTGCGCGCATTGCGACGCATGTTTGCGTGCATGGGCAAGGCCTAGG
CGGGCAGCTTCTCGCGTCGGCCGCACGGCGTTGCCTGCTCGCCGCAGCCGAAGCGGGCGGCGTGCTTCTTATCATCGATA
CAAAGAATGACCGCGCGGCAAAATGGTATGCGTCGTATGGCGCAGTTCCACTGAACAATAGGTCACTTACGCTTGTGATG
TCGCTTGCAACCTTTGCCGCTGAACTGAAAGCGGCCGATCAATCGCGTCCGGGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10387.20 Da        Isoelectric Point: 10.7279

>AT26253 WP_014449459.1 NC_017094:1305587-1305865 [Leptospirillum ferrooxidans C2-3]
MPRVAVNENKRMQLRIQPEQKATLMRAAALRNTTLTDFIFQIAMREAHVVIEEAERIRLSERDSLLVLDLLENPPAPNAK
LRGAIAAMPKPS

Download         Length: 279 bp

>AT26253 NC_017094:1305587-1305865 [Leptospirillum ferrooxidans C2-3]
ATGCCCAGAGTAGCCGTTAACGAGAACAAGCGGATGCAGCTTCGCATCCAGCCGGAGCAAAAAGCGACGCTTATGCGGGC
GGCCGCGCTTCGGAACACAACCCTAACGGATTTCATCTTTCAGATCGCCATGCGCGAGGCTCATGTCGTGATCGAGGAAG
CAGAGCGGATTCGACTGTCGGAAAGAGACAGCCTGCTGGTGCTGGATCTGCTGGAAAATCCGCCTGCGCCGAATGCCAAG
TTGCGCGGGGCCATTGCCGCGATGCCAAAACCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI0INX2

Antitoxin

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Source
ID
Structure
AlphaFold DBI0INX1

References