Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3106598..3107095 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OI124_RS15080 Protein ID WP_001173343.1
Coordinates 3106598..3106771 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag OI124_RS15085 Protein ID WP_001425728.1
Coordinates 3106799..3107095 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS15070 (3103268) 3103268..3104725 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
OI124_RS15075 (3104962) 3104962..3106479 + 1518 WP_001295074.1 lysine--tRNA ligase -
OI124_RS15080 (3106598) 3106598..3106771 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OI124_RS15085 (3106799) 3106799..3107095 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OI124_RS15090 (3107322) 3107322..3107594 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OI124_RS15095 (3107606) 3107606..3107836 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
OI124_RS15100 (3108017) 3108017..3109648 + 1632 WP_001216487.1 sensor histidine kinase -
OI124_RS15105 (3109645) 3109645..3110364 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T262529 WP_001173343.1 NZ_CP109953:c3106771-3106598 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT262529 WP_001425728.1 NZ_CP109953:c3107095-3106799 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References