Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2340559..2341177 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OI124_RS11390 Protein ID WP_001291435.1
Coordinates 2340959..2341177 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OI124_RS11385 Protein ID WP_000344800.1
Coordinates 2340559..2340933 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS11375 (2335648) 2335648..2336841 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OI124_RS11380 (2336864) 2336864..2340013 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OI124_RS11385 (2340559) 2340559..2340933 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OI124_RS11390 (2340959) 2340959..2341177 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OI124_RS11395 (2341349) 2341349..2341900 + 552 WP_000102568.1 maltose O-acetyltransferase -
OI124_RS11400 (2342016) 2342016..2342486 + 471 WP_000136192.1 YlaC family protein -
OI124_RS11405 (2342650) 2342650..2344200 + 1551 WP_048943370.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OI124_RS11410 (2344242) 2344242..2344595 - 354 Protein_2226 DUF1428 family protein -
OI124_RS11420 (2344974) 2344974..2345285 + 312 WP_000409911.1 MGMT family protein -
OI124_RS11425 (2345316) 2345316..2345888 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T262527 WP_001291435.1 NZ_CP109953:2340959-2341177 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT262527 WP_000344800.1 NZ_CP109953:2340559-2340933 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References