Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 133907..134532 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OI124_RS00615 Protein ID WP_000911330.1
Coordinates 134134..134532 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag OI124_RS00610 Protein ID WP_000450524.1
Coordinates 133907..134134 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS00585 (129710) 129710..130180 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
OI124_RS00590 (130180) 130180..130752 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
OI124_RS00595 (130898) 130898..131776 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
OI124_RS00600 (131793) 131793..132827 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
OI124_RS00605 (133040) 133040..133753 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OI124_RS00610 (133907) 133907..134134 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
OI124_RS00615 (134134) 134134..134532 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
OI124_RS00620 (134679) 134679..135542 + 864 WP_001267507.1 neutral zinc metallopeptidase -
OI124_RS00625 (135557) 135557..137572 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
OI124_RS00630 (137646) 137646..138344 + 699 WP_000679823.1 esterase -
OI124_RS00635 (138454) 138454..138654 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T262520 WP_000911330.1 NZ_CP109953:134134-134532 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT262520 WP_000450524.1 NZ_CP109953:133907-134134 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References