Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 615624..616034 Replicon chromosome
Accession NC_017094
Organism Leptospirillum ferrooxidans C2-3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LFE_RS03230 Protein ID WP_041773983.1
Coordinates 615624..615818 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID I0IM51
Locus tag LFE_RS03235 Protein ID WP_014448842.1
Coordinates 615828..616034 (+) Length 69 a.a.

Genomic Context

LFE_RS03210LFE_RS13555LFE_RS03230LFE_RS03235LFE_RS03215LFE_RS03220LFE_RS03240LFE_RS03245LFE_RS03255
Location: 612591..612917 (327 bp)
Type: Others
Protein ID: WP_198408011.1
Location: 613817..613963 (147 bp)
Type: Others
Protein ID: WP_198408012.1
Location: 615624..615818 (195 bp)
Type: Toxin
Protein ID: WP_041773983.1
Location: 615828..616034 (207 bp)
Type: Antitoxin
Protein ID: WP_014448842.1
Location: 613092..613418 (327 bp)
Type: Others
Protein ID: WP_014448838.1
Location: 614061..615131 (1071 bp)
Type: Others
Protein ID: WP_014448840.1
Location: 616452..616919 (468 bp)
Type: Others
Protein ID: WP_014448843.1
Location: 617221..618960 (1740 bp)
Type: Others
Protein ID: WP_041773984.1
Location: 619675..620349 (675 bp)
Type: Others
Protein ID: WP_014448846.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFE_RS03210612591..612917+327WP_198408011.1aldo/keto reductase-
LFE_RS03215613092..613418-327WP_014448838.1hypothetical protein-
LFE_RS13555613817..613963+147WP_198408012.12,5-didehydrogluconate reductase-
LFE_RS03220614061..615131-1071WP_014448840.1transposase-
LFE_RS03230615624..615818+195WP_041773983.1type II toxin-antitoxin system HicA family toxinToxin
LFE_RS03235615828..616034+207WP_014448842.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
LFE_RS03240616452..616919-468WP_014448843.1peptide-methionine (R)-S-oxide reductase MsrB-
LFE_RS03245617221..618960-1740WP_041773984.1methyltransferase domain-containing protein-
LFE_RS03255619675..620349-675WP_014448846.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7079.19 Da        Isoelectric Point: 10.8831

>T26252 WP_041773983.1 NC_017094:615624-615818 [Leptospirillum ferrooxidans C2-3]
MKVSEVLDLLKQDGWFLVDTRGSHRQFKHSLKPGRVTVAGKTSDDLSPGTLNSILKQSGLKTKK

Download         Length: 195 bp

>T26252 NC_017094:615624-615818 [Leptospirillum ferrooxidans C2-3]
ATGAAAGTTTCCGAGGTTCTTGATCTTCTAAAACAAGACGGCTGGTTTCTAGTCGATACGAGGGGAAGTCATCGACAATT
TAAACACTCTCTCAAACCCGGCCGGGTTACAGTGGCTGGGAAAACAAGCGATGATCTTTCCCCTGGAACATTGAACAGCA
TTTTGAAGCAGTCCGGCTTAAAAACAAAGAAATAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7600.62 Da        Isoelectric Point: 4.1007

>AT26252 WP_014448842.1 NC_017094:615828-616034 [Leptospirillum ferrooxidans C2-3]
MRYAIVIEKMESNYSAYVPDLPGCIATGSTIEETESLIKEAIAFHLEGMREDHQPVPEPTSLVEYVSI

Download         Length: 207 bp

>AT26252 NC_017094:615828-616034 [Leptospirillum ferrooxidans C2-3]
ATGCGTTATGCTATTGTTATTGAAAAAATGGAATCGAACTATTCTGCGTATGTTCCTGATCTCCCCGGCTGTATTGCGAC
CGGATCCACGATTGAAGAGACAGAGAGTTTAATTAAGGAGGCGATTGCTTTTCATCTTGAAGGAATGCGGGAAGATCATC
AACCCGTCCCGGAACCGACGAGTCTTGTGGAATATGTTTCTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBI0IM51

References