Detailed information of TA system TA026252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 615624..616034
• Replicon: chromosome
• Accession: NC_017094
• Organism: Leptospirillum ferrooxidans C2-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LFE_RS03230
• Protein ID: WP_041773983.1
• Coordinates: 615624..615818 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0IM51
• Locus tag: LFE_RS03235
• Protein ID: WP_014448842.1
• Coordinates: 615828..616034 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFE_RS03210	612591..612917	+	327	WP_198408011.1	aldo/keto reductase	-
LFE_RS03215	613092..613418	-	327	WP_014448838.1	hypothetical protein	-
LFE_RS13555	613817..613963	+	147	WP_198408012.1	2,5-didehydrogluconate reductase	-
LFE_RS03220	614061..615131	-	1071	WP_014448840.1	transposase	-
LFE_RS03230	615624..615818	+	195	WP_041773983.1	type II toxin-antitoxin system HicA family toxin	Toxin
LFE_RS03235	615828..616034	+	207	WP_014448842.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LFE_RS03240	616452..616919	-	468	WP_014448843.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LFE_RS03245	617221..618960	-	1740	WP_041773984.1	methyltransferase domain-containing protein	-
LFE_RS03255	619675..620349	-	675	WP_014448846.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7079.19 Da
• Isoelectric Point: 10.8831

>T26252 WP_041773983.1 NC_017094:615624-615818 [Leptospirillum ferrooxidans C2-3]
MKVSEVLDLLKQDGWFLVDTRGSHRQFKHSLKPGRVTVAGKTSDDLSPGTLNSILKQSGLKTKK

Nucleotide

• Length: 195 bp

>T26252 NC_017094:615624-615818 [Leptospirillum ferrooxidans C2-3]
ATGAAAGTTTCCGAGGTTCTTGATCTTCTAAAACAAGACGGCTGGTTTCTAGTCGATACGAGGGGAAGTCATCGACAATT
TAAACACTCTCTCAAACCCGGCCGGGTTACAGTGGCTGGGAAAACAAGCGATGATCTTTCCCCTGGAACATTGAACAGCA
TTTTGAAGCAGTCCGGCTTAAAAACAAAGAAATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7600.62 Da
• Isoelectric Point: 4.1007

>AT26252 WP_014448842.1 NC_017094:615828-616034 [Leptospirillum ferrooxidans C2-3]
MRYAIVIEKMESNYSAYVPDLPGCIATGSTIEETESLIKEAIAFHLEGMREDHQPVPEPTSLVEYVSI

Nucleotide

• Length: 207 bp

>AT26252 NC_017094:615828-616034 [Leptospirillum ferrooxidans C2-3]
ATGCGTTATGCTATTGTTATTGAAAAAATGGAATCGAACTATTCTGCGTATGTTCCTGATCTCCCCGGCTGTATTGCGAC
CGGATCCACGATTGAAGAGACAGAGAGTTTAATTAAGGAGGCGATTGCTTTTCATCTTGAAGGAATGCGGGAAGATCATC
AACCCGTCCCGGAACCGACGAGTCTTGTGGAATATGTTTCTATCTGA

Structures

Antitoxin

• AlphaFold DB: I0IM51