262519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 9725..10305 Replicon plasmid pKP1650-4
Accession NZ_CP109952
Organism Klebsiella pneumoniae strain KP1650

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag OIS41_RS29250 Protein ID WP_071177730.1
Coordinates 9725..10039 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag OIS41_RS29255 Protein ID WP_000093040.1
Coordinates 10027..10305 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIS41_RS29225 (OIS41_29230) 5669..7633 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
OIS41_RS29230 (OIS41_29235) 7633..8364 + 732 WP_071177728.1 MobC family replication-relaxation protein -
OIS41_RS29235 (OIS41_29240) 8371..8901 + 531 WP_071177729.1 hypothetical protein -
OIS41_RS29240 (OIS41_29245) 8928..9107 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
OIS41_RS29245 (OIS41_29250) 9133..9561 - 429 WP_001140599.1 hypothetical protein -
OIS41_RS29250 (OIS41_29255) 9725..10039 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIS41_RS29255 (OIS41_29260) 10027..10305 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
OIS41_RS29260 (OIS41_29265) 10480..10845 - 366 WP_072354022.1 TonB family protein -
OIS41_RS29265 (OIS41_29270) 10842..11213 - 372 WP_001237044.1 cell envelope integrity protein TolA -
OIS41_RS29270 (OIS41_29275) 11487..11732 - 246 WP_032440458.1 hypothetical protein -
OIS41_RS29275 (OIS41_29280) 12377..13864 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23943 23943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T262519 WP_071177730.1 NZ_CP109952:c10039-9725 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT262519 WP_000093040.1 NZ_CP109952:c10305-10027 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References