Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 136220..136800 Replicon chromosome
Accession NC_017094
Organism Leptospirillum ferrooxidans C2-3

Toxin (Protein)


Gene name PumA Uniprot ID I0IKS1
Locus tag LFE_RS00710 Protein ID WP_014448365.1
Coordinates 136220..136522 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I0IKS2
Locus tag LFE_RS00715 Protein ID WP_014448366.1
Coordinates 136519..136800 (+) Length 94 a.a.

Genomic Context

LFE_RS00655LFE_RS13490LFE_RS00700LFE_RS00710LFE_RS00715LFE_RS00725LFE_RS00730LFE_RS00660LFE_RS00665LFE_RS00670LFE_RS00680LFE_RS00685LFE_RS00690LFE_RS14030LFE_RS14035LFE_RS00720
Location: 131532..131939 (408 bp)
Type: Others
Protein ID: WP_014448354.1
Location: 135028..135321 (294 bp)
Type: Others
Protein ID: WP_081495298.1
Location: 135564..135917 (354 bp)
Type: Others
Protein ID: WP_014448363.1
Location: 136220..136522 (303 bp)
Type: Toxin
Protein ID: WP_014448365.1
Location: 136519..136800 (282 bp)
Type: Antitoxin
Protein ID: WP_014448366.1
Location: 138524..139528 (1005 bp)
Type: Others
Protein ID: WP_014448369.1
Location: 139563..140621 (1059 bp)
Type: Others
Protein ID: WP_014448370.1
Location: 131981..132388 (408 bp)
Type: Others
Protein ID: WP_014448355.1
Location: 132479..133315 (837 bp)
Type: Others
Protein ID: WP_014448356.1
Location: 133337..133531 (195 bp)
Type: Others
Protein ID: WP_014448357.1
Location: 133808..134095 (288 bp)
Type: Others
Protein ID: WP_014448359.1
Location: 134107..134397 (291 bp)
Type: Others
Protein ID: WP_014448360.1
Location: 134566..134778 (213 bp)
Type: Others
Protein ID: WP_014448361.1
Location: 136791..136943 (153 bp)
Type: Others
Protein ID: WP_014448367.1
Location: 136972..137112 (141 bp)
Type: Others
Protein ID: WP_158310225.1
Location: 137405..138343 (939 bp)
Type: Others
Protein ID: WP_014448368.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFE_RS00655131532..131939+408WP_014448354.1IS3 family transposase-
LFE_RS00660131981..132388-408WP_014448355.1hypothetical protein-
LFE_RS00665132479..133315-837WP_014448356.1hypothetical protein-
LFE_RS00670133337..133531-195WP_014448357.1hypothetical protein-
LFE_RS00680133808..134095-288WP_014448359.1putative addiction module antidote protein-
LFE_RS00685134107..134397-291WP_014448360.1type II toxin-antitoxin system RelE/ParE family toxin-
LFE_RS00690134566..134778-213WP_014448361.1DUF2283 domain-containing protein-
LFE_RS13490135028..135321+294WP_081495298.1tyrosine-type recombinase/integrase-
LFE_RS00700135564..135917+354WP_014448363.1hypothetical protein-
LFE_RS00710136220..136522+303WP_014448365.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LFE_RS00715136519..136800+282WP_014448366.1putative addiction module antidote proteinAntitoxin
LFE_RS14030136791..136943-153WP_014448367.1hypothetical protein-
LFE_RS14035136972..137112-141WP_158310225.1hypothetical protein-
LFE_RS00720137405..138343-939WP_014448368.1AraC family transcriptional regulator-
LFE_RS00725138524..139528+1005WP_014448369.1aldo/keto reductase-
LFE_RS00730139563..140621+1059WP_014448370.1NAD(P)-dependent alcohol dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--128618..14871020092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(15-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11234.01 Da        Isoelectric Point: 9.6544

>T26251 WP_014448365.1 NC_017094:136220-136522 [Leptospirillum ferrooxidans C2-3]
MIAVQQTETFAHWLSSLKDRSGLVRILSRLDRIAMGNFGDVKPVGEGVSEIRIDTGPGYRLYFVRQENTLILLLCGGDKS
TQDRDISLAKELKKTLEKKP

Download         Length: 303 bp

>T26251 NC_017094:136220-136522 [Leptospirillum ferrooxidans C2-3]
ATGATTGCCGTCCAGCAGACAGAAACCTTCGCGCATTGGCTTTCCTCTCTGAAGGATCGATCCGGACTGGTCCGGATCCT
GTCCCGCCTGGACAGAATCGCGATGGGAAATTTTGGTGACGTAAAGCCGGTAGGAGAGGGCGTTTCGGAAATCCGAATCG
ATACGGGACCCGGATACCGCCTGTATTTCGTCCGCCAGGAGAACACGTTGATTCTCCTGCTTTGCGGCGGGGACAAATCG
ACGCAAGACCGCGACATCTCTCTGGCAAAGGAATTGAAGAAAACCCTGGAGAAGAAACCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10248.86 Da        Isoelectric Point: 5.1373

>AT26251 WP_014448366.1 NC_017094:136519-136800 [Leptospirillum ferrooxidans C2-3]
MKEKILEFDPSVYLDSEETIAEYLTVTLEENDPDLLLAALSNVAKARGMSQIARESGLGRESLYKALTPGSKPRFETIMK
VMHALGVKLAVHA

Download         Length: 282 bp

>AT26251 NC_017094:136519-136800 [Leptospirillum ferrooxidans C2-3]
ATGAAAGAAAAAATTCTGGAATTCGATCCGTCGGTATATCTCGACAGCGAGGAAACCATTGCGGAATACCTGACCGTCAC
CCTTGAGGAGAACGATCCCGATCTTCTCCTAGCGGCTCTGTCCAACGTGGCCAAAGCACGCGGAATGTCCCAGATAGCTC
GGGAATCGGGGCTTGGGCGGGAAAGTCTTTACAAAGCCCTGACCCCCGGCTCCAAACCGCGCTTCGAAACGATCATGAAG
GTGATGCACGCGCTGGGCGTCAAACTGGCCGTTCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBI0IKS1

Antitoxin

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Source
ID
Structure
AlphaFold DBI0IKS2

References