Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5353368..5353993 Replicon chromosome
Accession NZ_CP109948
Organism Klebsiella pneumoniae strain KP1650

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OIS41_RS26335 Protein ID WP_002882817.1
Coordinates 5353368..5353751 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OIS41_RS26340 Protein ID WP_004150355.1
Coordinates 5353751..5353993 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIS41_RS26320 (OIS41_26325) 5350734..5351636 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OIS41_RS26325 (OIS41_26330) 5351633..5352268 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OIS41_RS26330 (OIS41_26335) 5352265..5353194 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OIS41_RS26335 (OIS41_26340) 5353368..5353751 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OIS41_RS26340 (OIS41_26345) 5353751..5353993 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OIS41_RS26345 (OIS41_26350) 5354198..5355115 + 918 WP_002882812.1 alpha/beta hydrolase -
OIS41_RS26350 (OIS41_26355) 5355129..5356070 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OIS41_RS26355 (OIS41_26360) 5356115..5356552 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OIS41_RS26360 (OIS41_26365) 5356549..5357409 - 861 WP_002882807.1 virulence factor BrkB family protein -
OIS41_RS26365 (OIS41_26370) 5357403..5358002 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T262504 WP_002882817.1 NZ_CP109948:c5353751-5353368 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT262504 WP_004150355.1 NZ_CP109948:c5353993-5353751 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References