262502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4871934..4872450 Replicon chromosome
Accession NZ_CP109948
Organism Klebsiella pneumoniae strain KP1650

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OIS41_RS24020 Protein ID WP_002886902.1
Coordinates 4871934..4872218 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OIS41_RS24025 Protein ID WP_002886901.1
Coordinates 4872208..4872450 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIS41_RS23995 (OIS41_24000) 4867418..4867681 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OIS41_RS24000 (OIS41_24005) 4867811..4867984 + 174 WP_002886906.1 hypothetical protein -
OIS41_RS24005 (OIS41_24010) 4867987..4868730 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OIS41_RS24010 (OIS41_24015) 4869087..4871225 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OIS41_RS24015 (OIS41_24020) 4871466..4871930 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OIS41_RS24020 (OIS41_24025) 4871934..4872218 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIS41_RS24025 (OIS41_24030) 4872208..4872450 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OIS41_RS24030 (OIS41_24035) 4872528..4874438 - 1911 WP_004152270.1 PRD domain-containing protein -
OIS41_RS24035 (OIS41_24040) 4874461..4875615 - 1155 WP_002886900.1 lactonase family protein -
OIS41_RS24040 (OIS41_24045) 4875681..4876421 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T262502 WP_002886902.1 NZ_CP109948:c4872218-4871934 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT262502 WP_002886901.1 NZ_CP109948:c4872450-4872208 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References