Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2762273..2763861 Replicon chromosome
Accession NZ_CP109948
Organism Klebsiella pneumoniae strain KP1650

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OIS41_RS13725 Protein ID WP_004199851.1
Coordinates 2762539..2763861 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OIS41_RS13720 Protein ID WP_002904790.1
Coordinates 2762273..2762539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIS41_RS13695 (OIS41_13695) 2757423..2758346 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
OIS41_RS13700 (OIS41_13700) 2758327..2759481 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OIS41_RS13705 (OIS41_13705) 2759827..2761206 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
OIS41_RS13710 (OIS41_13710) 2761184..2761684 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OIS41_RS13715 (OIS41_13715) 2761681..2762007 + 327 WP_002904788.1 hydroxyisourate hydrolase -
OIS41_RS13720 (OIS41_13720) 2762273..2762539 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OIS41_RS13725 (OIS41_13725) 2762539..2763861 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OIS41_RS13730 (OIS41_13730) 2763878..2765170 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OIS41_RS13735 (OIS41_13735) 2765303..2766307 - 1005 WP_004199852.1 fimbrial protein -
OIS41_RS13740 (OIS41_13740) 2766295..2768796 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T262495 WP_004199851.1 NZ_CP109948:2762539-2763861 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT262495 WP_002904790.1 NZ_CP109948:2762273-2762539 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References