Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 578839..580483 Replicon chromosome
Accession NZ_CP109947
Organism Pectobacterium cacticida strain CFCC10813

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OI450_RS02725 Protein ID WP_264497675.1
Coordinates 579149..580483 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OI450_RS02720 Protein ID WP_264497674.1
Coordinates 578839..579144 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI450_RS02695 (OI450_02695) 573980..574339 + 360 WP_264497673.1 type II toxin-antitoxin system RelE/ParE family toxin -
OI450_RS02700 (OI450_02700) 574323..574646 + 324 WP_039304754.1 DNA-binding transcriptional regulator -
OI450_RS02705 (OI450_02705) 574766..576187 + 1422 WP_256553918.1 ParB N-terminal domain-containing protein -
OI450_RS02710 (OI450_02710) 576253..577122 + 870 WP_205947181.1 DNA adenine methylase -
OI450_RS02715 (OI450_02715) 577573..578442 + 870 Protein_514 integrase arm-type DNA-binding domain-containing protein -
OI450_RS02720 (OI450_02720) 578839..579144 + 306 WP_264497674.1 helix-turn-helix transcriptional regulator Antitoxin
OI450_RS02725 (OI450_02725) 579149..580483 + 1335 WP_264497675.1 type II toxin-antitoxin system HipA family toxin Toxin
OI450_RS02730 (OI450_02730) 580517..580678 + 162 Protein_517 IS3 family transposase -
OI450_RS02735 (OI450_02735) 581058..582773 + 1716 WP_264497676.1 polysaccharide lyase family protein -
OI450_RS02740 (OI450_02740) 582823..583575 + 753 WP_264497677.1 oligogalacturonate-specific porin KdgM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50672.63 Da        Isoelectric Point: 5.5164

>T262483 WP_264497675.1 NZ_CP109947:579149-580483 [Pectobacterium cacticida]
MPRTQQRLAIWMNGIQVGFWEKIRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQMWRGNVVRDYFDNLLPDSEGIRRRL
ATRYQADSLEPFDLLAELGRDCVGAIQLLNGNEEPADLFSVNYRPLSEAEIAAILRNTTASLLPGRQDDADDVRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNRQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSEQAEQDKARFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVVGPRNNQISWQTCTLAMAVRGSSNYYHLYRIQRRHWVNQGELTGLGRRQVEAMMDDI
ISRTPEVIERVSALLPESFPPALAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11311.13 Da        Isoelectric Point: 10.3119

>AT262483 WP_264497674.1 NZ_CP109947:578839-579144 [Pectobacterium cacticida]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEMVLSSGPNVHLSL
SFPTMEESEKPIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References