Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 434837..435465 Replicon chromosome
Accession NZ_CP109945
Organism Lacticaseibacillus paracasei subsp. tolerans strain FX-6-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OH135_RS02075 Protein ID WP_076652662.1
Coordinates 435097..435465 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag OH135_RS02070 Protein ID WP_003583264.1
Coordinates 434837..435097 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH135_RS02040 (OH135_02040) 430627..431157 + 531 WP_012490988.1 DNA-directed RNA polymerase subunit sigma-24 -
OH135_RS02045 (OH135_02045) 431325..431477 + 153 WP_003563363.1 YvrJ family protein -
OH135_RS02050 (OH135_02050) 431487..432251 + 765 WP_016387929.1 GH25 family lysozyme -
OH135_RS02055 (OH135_02055) 432462..432965 + 504 WP_003563372.1 TetR/AcrR family transcriptional regulator -
OH135_RS02060 (OH135_02060) 432970..434031 + 1062 WP_016387927.1 ABC transporter permease -
OH135_RS02065 (OH135_02065) 434036..434725 + 690 WP_016387926.1 ABC transporter ATP-binding protein -
OH135_RS02070 (OH135_02070) 434837..435097 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
OH135_RS02075 (OH135_02075) 435097..435465 - 369 WP_076652662.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH135_RS02080 (OH135_02080) 435757..437127 - 1371 WP_016387925.1 FAD-dependent oxidoreductase -
OH135_RS02085 (OH135_02085) 437491..438309 - 819 WP_019914724.1 Cof-type HAD-IIB family hydrolase -
OH135_RS02090 (OH135_02090) 438626..438895 - 270 WP_003563382.1 type II toxin-antitoxin system YafQ family toxin -
OH135_RS02095 (OH135_02095) 439136..440143 + 1008 WP_076652659.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14969.10 Da        Isoelectric Point: 8.0915

>T262481 WP_076652662.1 NZ_CP109945:c435465-435097 [Lacticaseibacillus paracasei subsp. tolerans]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLCPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQANLEDWLSRKEEN

Download         Length: 369 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT262481 WP_003583264.1 NZ_CP109945:c435097-434837 [Lacticaseibacillus paracasei subsp. tolerans]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References