262473

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 890920..892163 Replicon chromosome
Accession NZ_CP109942
Organism Streptococcus suis strain ID35541

Toxin (Protein)


Gene name pezA Uniprot ID -
Locus tag OHM48_RS04390 Protein ID WP_074394313.1
Coordinates 890920..891687 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag OHM48_RS04395 Protein ID WP_002935067.1
Coordinates 891687..892163 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM48_RS04375 (OHM48_04375) 887308..887673 - 366 WP_018163914.1 plasmid mobilization relaxosome protein MobC -
OHM48_RS04380 (OHM48_04380) 887683..888042 - 360 WP_002935059.1 SAG1252 family conjugative relaxosome accessory protein -
OHM48_RS04385 (OHM48_04385) 888377..890884 - 2508 WP_002935064.1 AAA family ATPase -
OHM48_RS04390 (OHM48_04390) 890920..891687 - 768 WP_074394313.1 type II toxin-antitoxin system toxin PezT Toxin
OHM48_RS04395 (OHM48_04395) 891687..892163 - 477 WP_002935067.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
OHM48_RS04400 (OHM48_04400) 892233..892523 - 291 WP_000667951.1 hypothetical protein -
OHM48_RS04405 (OHM48_04405) 892573..892962 - 390 WP_044475264.1 DUF5945 family protein -
OHM48_RS04410 (OHM48_04410) 892959..893186 - 228 WP_000110922.1 DUF5965 family protein -
OHM48_RS04415 (OHM48_04415) 893214..894314 - 1101 WP_014636297.1 toprim domain-containing protein -
OHM48_RS04420 (OHM48_04420) 894354..894992 - 639 WP_014636296.1 hypothetical protein -
OHM48_RS04425 (OHM48_04425) 895087..895377 - 291 WP_000893083.1 DUF5966 family protein -
OHM48_RS04430 (OHM48_04430) 895391..895690 - 300 WP_014636295.1 DUF5962 family protein -
OHM48_RS04435 (OHM48_04435) 895761..896720 - 960 Protein_826 hypothetical protein -
OHM48_RS04440 (OHM48_04440) 896713..897034 - 322 Protein_827 DUF4368 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3')-III / ant(6)-Ia / erm(B) / tet(O) - 873579..918936 45357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 28903.81 Da        Isoelectric Point: 5.4388

>T262473 WP_074394313.1 NZ_CP109942:c891687-890920 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLICYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18273.67 Da        Isoelectric Point: 4.3971

>AT262473 WP_002935067.1 NZ_CP109942:c892163-891687 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References