262472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 858493..858985 Replicon chromosome
Accession NZ_CP109942
Organism Streptococcus suis strain ID35541

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag OHM48_RS04225 Protein ID WP_011922404.1
Coordinates 858493..858750 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag OHM48_RS04230 Protein ID WP_012775104.1
Coordinates 858734..858985 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM48_RS04205 (OHM48_04205) 854127..855197 + 1071 WP_012775101.1 tyrosine recombinase XerS -
OHM48_RS04210 (OHM48_04210) 855267..856775 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
OHM48_RS04215 (OHM48_04215) 856851..857792 - 942 WP_012775102.1 sensor histidine kinase -
OHM48_RS04220 (OHM48_04220) 857789..858454 - 666 WP_012775103.1 response regulator transcription factor -
OHM48_RS04225 (OHM48_04225) 858493..858750 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM48_RS04230 (OHM48_04230) 858734..858985 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
OHM48_RS04235 (OHM48_04235) 859077..861047 - 1971 WP_074411944.1 FtsX-like permease family protein -
OHM48_RS04240 (OHM48_04240) 861048..861800 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
OHM48_RS04245 (OHM48_04245) 861936..862670 - 735 WP_011922410.1 ABC transporter permease -
OHM48_RS04250 (OHM48_04250) 862672..863418 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T262472 WP_011922404.1 NZ_CP109942:c858750-858493 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT262472 WP_012775104.1 NZ_CP109942:c858985-858734 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References