262471

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 594148..594634 Replicon chromosome
Accession NZ_CP109942
Organism Streptococcus suis strain ID35541

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag OHM48_RS02970 Protein ID WP_011922754.1
Coordinates 594365..594634 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag OHM48_RS02965 Protein ID WP_002938604.1
Coordinates 594148..594375 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM48_RS02940 (OHM48_02940) 589191..589640 - 450 WP_009909619.1 MarR family transcriptional regulator -
OHM48_RS02945 (OHM48_02945) 589934..590781 + 848 WP_094122532.1 IS630 family transposase -
OHM48_RS02950 (OHM48_02950) 590840..591337 + 498 WP_011922751.1 DUF5590 domain-containing protein -
OHM48_RS02955 (OHM48_02955) 591334..592515 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
OHM48_RS02960 (OHM48_02960) 592530..593876 + 1347 WP_011922752.1 asparagine--tRNA ligase -
OHM48_RS02965 (OHM48_02965) 594148..594375 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
OHM48_RS02970 (OHM48_02970) 594365..594634 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM48_RS02975 (OHM48_02975) 595039..596359 + 1321 Protein_537 MATE family efflux transporter -
OHM48_RS02980 (OHM48_02980) 596410..596787 + 378 WP_002937263.1 RidA family protein -
OHM48_RS02985 (OHM48_02985) 596809..597696 + 888 WP_011922160.1 RNase adapter RapZ -
OHM48_RS02990 (OHM48_02990) 597693..598667 + 975 WP_002937257.1 YvcK family protein -
OHM48_RS02995 (OHM48_02995) 598664..599581 + 918 WP_105155745.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T262471 WP_011922754.1 NZ_CP109942:594365-594634 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT262471 WP_002938604.1 NZ_CP109942:594148-594375 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References