Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 865094..865586 Replicon chromosome
Accession NZ_CP109941
Organism Streptococcus suis strain ID38828

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag OHM51_RS04260 Protein ID WP_011922404.1
Coordinates 865094..865351 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag OHM51_RS04265 Protein ID WP_012775104.1
Coordinates 865335..865586 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM51_RS04240 (OHM51_04240) 860728..861798 + 1071 WP_012775101.1 tyrosine recombinase XerS -
OHM51_RS04245 (OHM51_04245) 861868..863376 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
OHM51_RS04250 (OHM51_04250) 863452..864393 - 942 WP_012775102.1 sensor histidine kinase -
OHM51_RS04255 (OHM51_04255) 864390..865055 - 666 WP_012775103.1 response regulator transcription factor -
OHM51_RS04260 (OHM51_04260) 865094..865351 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM51_RS04265 (OHM51_04265) 865335..865586 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
OHM51_RS04270 (OHM51_04270) 865678..867648 - 1971 WP_012775105.1 FtsX-like permease family protein -
OHM51_RS04275 (OHM51_04275) 867649..868401 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
OHM51_RS04280 (OHM51_04280) 868537..869271 - 735 WP_011922410.1 ABC transporter permease -
OHM51_RS04285 (OHM51_04285) 869273..870019 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T262467 WP_011922404.1 NZ_CP109941:c865351-865094 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT262467 WP_012775104.1 NZ_CP109941:c865586-865335 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References