262464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1891755..1893187 Replicon chromosome
Accession NZ_CP109940
Organism Streptococcus suis strain ID34572

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z8TB64
Locus tag OHM49_RS09400 Protein ID WP_024394846.1
Coordinates 1892342..1893187 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0Z8SSH7
Locus tag OHM49_RS09395 Protein ID WP_002935109.1
Coordinates 1891755..1892345 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM49_RS09365 (OHM49_09365) 1887367..1889022 - 1656 WP_249547177.1 peptide cleavage/export ABC transporter -
OHM49_RS09370 (OHM49_09370) 1889225..1889416 - 192 WP_002935101.1 hypothetical protein -
OHM49_RS09375 (OHM49_09375) 1889505..1889777 - 273 WP_002935103.1 DUF3884 family protein -
OHM49_RS09380 (OHM49_09380) 1889806..1890045 - 240 WP_044674089.1 hypothetical protein -
OHM49_RS09385 (OHM49_09385) 1890080..1891123 - 1044 WP_228477119.1 glycosyltransferase family 2 protein -
OHM49_RS09390 (OHM49_09390) 1891311..1891472 - 162 WP_002935108.1 agglutinin receptor -
OHM49_RS09395 (OHM49_09395) 1891755..1892345 + 591 WP_002935109.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
OHM49_RS09400 (OHM49_09400) 1892342..1893187 + 846 WP_024394846.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OHM49_RS09405 (OHM49_09405) 1893249..1896050 - 2802 WP_014636948.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cpsI 1809960..1935245 125285
- flank IS/Tn - - 1886259..1887263 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32466.18 Da        Isoelectric Point: 5.4404

>T262464 WP_024394846.1 NZ_CP109940:1892342-1893187 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23299.86 Da        Isoelectric Point: 7.8482

>AT262464 WP_002935109.1 NZ_CP109940:1891755-1892345 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8TB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8SSH7

References