Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 980216..981459 Replicon chromosome
Accession NZ_CP109940
Organism Streptococcus suis strain ID34572

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag OHM49_RS04900 Protein ID WP_263928773.1
Coordinates 980216..980983 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag OHM49_RS04905 Protein ID WP_000578719.1
Coordinates 980983..981459 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM49_RS04885 (OHM49_04885) 976621..976986 - 366 WP_014636932.1 MobC family plasmid mobilization relaxosome protein -
OHM49_RS04890 (OHM49_04890) 976993..977355 - 363 WP_014636933.1 SAG1252 family conjugative relaxosome accessory protein -
OHM49_RS04895 (OHM49_04895) 977672..980215 - 2544 WP_000601012.1 AAA family ATPase -
OHM49_RS04900 (OHM49_04900) 980216..980983 - 768 WP_263928773.1 type II toxin-antitoxin system toxin PezT Toxin
OHM49_RS04905 (OHM49_04905) 980983..981459 - 477 WP_000578719.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
OHM49_RS04910 (OHM49_04910) 981529..981819 - 291 WP_263928772.1 hypothetical protein -
OHM49_RS04915 (OHM49_04915) 981869..982258 - 390 WP_000048066.1 DUF5945 family protein -
OHM49_RS04920 (OHM49_04920) 982255..982482 - 228 WP_000110922.1 DUF5965 family protein -
OHM49_RS04925 (OHM49_04925) 982510..983610 - 1101 WP_000196860.1 toprim domain-containing protein -
OHM49_RS04930 (OHM49_04930) 983674..985317 - 1644 WP_002935076.1 recombinase family protein -
OHM49_RS04935 (OHM49_04935) 985443..986339 + 897 WP_001809760.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29001.85 Da        Isoelectric Point: 5.1126

>T262463 WP_263928773.1 NZ_CP109940:c980983-980216 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATLKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT262463 WP_000578719.1 NZ_CP109940:c981459-980983 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References