262462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 958795..959281 Replicon chromosome
Accession NZ_CP109940
Organism Streptococcus suis strain ID34572

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag OHM49_RS04785 Protein ID WP_002935012.1
Coordinates 958795..959052 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag OHM49_RS04790 Protein ID WP_002935014.1
Coordinates 959042..959281 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM49_RS04765 (OHM49_04765) 954429..955499 + 1071 WP_002935006.1 tyrosine recombinase XerS -
OHM49_RS04770 (OHM49_04770) 955569..957077 - 1509 WP_013730362.1 phosphoglucomutase -
OHM49_RS04775 (OHM49_04775) 957153..958094 - 942 WP_002935009.1 sensor histidine kinase -
OHM49_RS04780 (OHM49_04780) 958091..958756 - 666 WP_009909826.1 response regulator transcription factor -
OHM49_RS04785 (OHM49_04785) 958795..959052 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM49_RS04790 (OHM49_04790) 959042..959281 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
OHM49_RS04795 (OHM49_04795) 959373..961343 - 1971 WP_013730363.1 FtsX-like permease family protein -
OHM49_RS04800 (OHM49_04800) 961344..962096 - 753 WP_172092511.1 ABC transporter ATP-binding protein -
OHM49_RS04805 (OHM49_04805) 962232..962966 - 735 WP_011922410.1 ABC transporter permease -
OHM49_RS04810 (OHM49_04810) 962968..963714 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 904895..979442 74547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T262462 WP_002935012.1 NZ_CP109940:c959052-958795 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT262462 WP_002935014.1 NZ_CP109940:c959281-959042 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References