Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 719286..720837 Replicon chromosome
Accession NZ_CP109940
Organism Streptococcus suis strain ID34572

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OHM49_RS03560 Protein ID WP_079739431.1
Coordinates 719560..720837 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OHM49_RS03555 Protein ID WP_000301765.1
Coordinates 719286..719558 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM49_RS03520 (OHM49_03520) 714714..715055 + 342 Protein_660 recombinase family protein -
OHM49_RS03525 (OHM49_03525) 715131..715226 + 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
OHM49_RS03530 (OHM49_03530) 715351..716088 + 738 WP_012477196.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OHM49_RS03535 (OHM49_03535) 716258..716518 + 261 Protein_663 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
OHM49_RS03540 (OHM49_03540) 716591..717942 + 1352 WP_105152558.1 IS3 family transposase -
OHM49_RS03545 (OHM49_03545) 718065..718961 + 897 WP_002334978.1 AAA family ATPase -
OHM49_RS03550 (OHM49_03550) 719060..719269 + 210 WP_000527318.1 peptide-binding protein -
OHM49_RS03555 (OHM49_03555) 719286..719558 + 273 WP_000301765.1 antitoxin Antitoxin
OHM49_RS03560 (OHM49_03560) 719560..720837 + 1278 WP_079739431.1 zeta toxin family protein Toxin
OHM49_RS03565 (OHM49_03565) 720924..721721 + 798 WP_053866438.1 AAA family ATPase -
OHM49_RS03570 (OHM49_03570) 721768..721983 + 216 WP_053866437.1 hypothetical protein -
OHM49_RS03575 (OHM49_03575) 722157..723506 + 1350 WP_053866436.1 ISLre2 family transposase -
OHM49_RS03580 (OHM49_03580) 723892..724167 + 276 WP_002936247.1 HU family DNA-binding protein -
OHM49_RS03585 (OHM49_03585) 724683..725150 + 468 WP_043033030.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage erm(B) - 714714..725150 10436
- flank IS/Tn erm(B) - 715351..717942 2591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 48802.57 Da        Isoelectric Point: 9.0764

>T262461 WP_079739431.1 NZ_CP109940:719560-720837 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Download         Length: 1278 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT262461 WP_000301765.1 NZ_CP109940:719286-719558 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References