Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1332538..1334089 Replicon chromosome
Accession NZ_CP109939
Organism Streptococcus suis strain ID36054

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OHM47_RS06840 Protein ID WP_079739431.1
Coordinates 1332538..1333815 (-) Length 426 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OHM47_RS06845 Protein ID WP_000301765.1
Coordinates 1333817..1334089 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM47_RS06815 (OHM47_06815) 1328168..1328635 - 468 WP_043033030.1 GNAT family N-acetyltransferase -
OHM47_RS06820 (OHM47_06820) 1329208..1329483 - 276 WP_002936247.1 HU family DNA-binding protein -
OHM47_RS06825 (OHM47_06825) 1329869..1331218 - 1350 WP_053866436.1 ISLre2 family transposase -
OHM47_RS06830 (OHM47_06830) 1331392..1331607 - 216 WP_053866437.1 hypothetical protein -
OHM47_RS06835 (OHM47_06835) 1331654..1332451 - 798 WP_053866438.1 AAA family ATPase -
OHM47_RS06840 (OHM47_06840) 1332538..1333815 - 1278 WP_079739431.1 zeta toxin family protein Toxin
OHM47_RS06845 (OHM47_06845) 1333817..1334089 - 273 WP_000301765.1 antitoxin Antitoxin
OHM47_RS06850 (OHM47_06850) 1334106..1334315 - 210 WP_000527318.1 peptide-binding protein -
OHM47_RS06855 (OHM47_06855) 1334414..1335310 - 897 WP_002334978.1 AAA family ATPase -
OHM47_RS06860 (OHM47_06860) 1335413..1335673 - 261 Protein_1326 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
OHM47_RS06865 (OHM47_06865) 1335843..1336580 - 738 WP_012477196.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OHM47_RS06870 (OHM47_06870) 1336705..1336800 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
OHM47_RS06875 (OHM47_06875) 1336876..1337217 - 342 Protein_1329 recombinase family protein -
OHM47_RS06880 (OHM47_06880) 1337569..1337886 - 318 WP_053866439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 48802.57 Da        Isoelectric Point: 9.0764

>T262459 WP_079739431.1 NZ_CP109939:c1333815-1332538 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Download         Length: 1278 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT262459 WP_000301765.1 NZ_CP109939:c1334089-1333817 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References