Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1092541..1093027 Replicon chromosome
Accession NZ_CP109939
Organism Streptococcus suis strain ID36054

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag OHM47_RS05600 Protein ID WP_002935012.1
Coordinates 1092770..1093027 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag OHM47_RS05595 Protein ID WP_002935014.1
Coordinates 1092541..1092780 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM47_RS05575 (OHM47_05575) 1088107..1088853 + 747 WP_011922411.1 ABC transporter permease -
OHM47_RS05580 (OHM47_05580) 1088855..1089589 + 735 WP_011922410.1 ABC transporter permease -
OHM47_RS05585 (OHM47_05585) 1089725..1090477 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
OHM47_RS05590 (OHM47_05590) 1090478..1092449 + 1972 Protein_1075 FtsX-like permease family protein -
OHM47_RS05595 (OHM47_05595) 1092541..1092780 + 240 WP_002935014.1 DUF6290 family protein Antitoxin
OHM47_RS05600 (OHM47_05600) 1092770..1093027 + 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM47_RS05605 (OHM47_05605) 1093066..1093731 + 666 WP_009909826.1 response regulator transcription factor -
OHM47_RS05610 (OHM47_05610) 1093728..1094669 + 942 WP_002935009.1 sensor histidine kinase -
OHM47_RS05615 (OHM47_05615) 1094745..1096253 + 1509 WP_013730362.1 phosphoglucomutase -
OHM47_RS05620 (OHM47_05620) 1096323..1097393 - 1071 WP_002935006.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) - 1042142..1105122 62980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T262458 WP_002935012.1 NZ_CP109939:1092770-1093027 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT262458 WP_002935014.1 NZ_CP109939:1092541-1092780 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References