Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 216021..217453 | Replicon | chromosome |
| Accession | NZ_CP109939 | ||
| Organism | Streptococcus suis strain ID36054 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | A0A0Z8TB64 |
| Locus tag | OHM47_RS01230 | Protein ID | WP_024394846.1 |
| Coordinates | 216021..216866 (-) | Length | 282 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | A0A0Z8SSH7 |
| Locus tag | OHM47_RS01235 | Protein ID | WP_002935109.1 |
| Coordinates | 216863..217453 (-) | Length | 197 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OHM47_RS01225 (OHM47_01225) | 213158..215959 | + | 2802 | WP_264495594.1 | phage tail tip lysozyme | - |
| OHM47_RS01230 (OHM47_01230) | 216021..216866 | - | 846 | WP_024394846.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OHM47_RS01235 (OHM47_01235) | 216863..217453 | - | 591 | WP_002935109.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| OHM47_RS01240 (OHM47_01240) | 217736..217897 | + | 162 | WP_002935108.1 | agglutinin receptor | - |
| OHM47_RS01245 (OHM47_01245) | 218085..219401 | + | 1317 | WP_002935107.1 | glycosyltransferase family 2 protein | - |
| OHM47_RS01250 (OHM47_01250) | 219430..219702 | + | 273 | WP_002935103.1 | DUF3884 family protein | - |
| OHM47_RS01255 (OHM47_01255) | 219791..219982 | + | 192 | WP_002935101.1 | hypothetical protein | - |
| OHM47_RS01260 (OHM47_01260) | 220185..221840 | + | 1656 | WP_249547177.1 | peptide cleavage/export ABC transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 157147..260946 | 103799 | |
| - | flank | IS/Tn | - | - | 221944..222948 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 282 a.a. Molecular weight: 32466.18 Da Isoelectric Point: 5.4404
>T262457 WP_024394846.1 NZ_CP109939:c216866-216021 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD
Download Length: 846 bp
Antitoxin
Download Length: 197 a.a. Molecular weight: 23299.86 Da Isoelectric Point: 7.8482
>AT262457 WP_002935109.1 NZ_CP109939:c217453-216863 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV
Download Length: 591 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z8TB64 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z8SSH7 |