262455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1896488..1897920 Replicon chromosome
Accession NZ_CP109937
Organism Streptococcus suis strain TRG6

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z8TB64
Locus tag OHM52_RS09445 Protein ID WP_024394846.1
Coordinates 1897075..1897920 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0Z8SSH7
Locus tag OHM52_RS09440 Protein ID WP_002935109.1
Coordinates 1896488..1897078 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM52_RS09410 (OHM52_09410) 1892102..1893757 - 1656 WP_249547177.1 peptide cleavage/export ABC transporter -
OHM52_RS09415 (OHM52_09415) 1893960..1894151 - 192 WP_002935101.1 hypothetical protein -
OHM52_RS09420 (OHM52_09420) 1894240..1894512 - 273 WP_002935103.1 DUF3884 family protein -
OHM52_RS09425 (OHM52_09425) 1894541..1894780 - 240 WP_044674089.1 hypothetical protein -
OHM52_RS09430 (OHM52_09430) 1894828..1895856 - 1029 WP_228476962.1 glycosyltransferase family 2 protein -
OHM52_RS09435 (OHM52_09435) 1896044..1896205 - 162 WP_002935108.1 agglutinin receptor -
OHM52_RS09440 (OHM52_09440) 1896488..1897078 + 591 WP_002935109.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
OHM52_RS09445 (OHM52_09445) 1897075..1897920 + 846 WP_024394846.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OHM52_RS09450 (OHM52_09450) 1897982..1900783 - 2802 WP_014636948.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cpsI 1814695..1939962 125267
- flank IS/Tn - - 1890994..1891998 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32466.18 Da        Isoelectric Point: 5.4404

>T262455 WP_024394846.1 NZ_CP109937:1897075-1897920 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23299.86 Da        Isoelectric Point: 7.8482

>AT262455 WP_002935109.1 NZ_CP109937:1896488-1897078 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8TB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8SSH7

References