262453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 963434..963920 Replicon chromosome
Accession NZ_CP109937
Organism Streptococcus suis strain TRG6

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag OHM52_RS04835 Protein ID WP_002935012.1
Coordinates 963434..963691 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag OHM52_RS04840 Protein ID WP_002935014.1
Coordinates 963681..963920 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM52_RS04815 (OHM52_04815) 959068..960138 + 1071 WP_002935006.1 tyrosine recombinase XerS -
OHM52_RS04820 (OHM52_04820) 960208..961716 - 1509 WP_013730362.1 phosphoglucomutase -
OHM52_RS04825 (OHM52_04825) 961792..962733 - 942 WP_002935009.1 sensor histidine kinase -
OHM52_RS04830 (OHM52_04830) 962730..963395 - 666 WP_009909826.1 response regulator transcription factor -
OHM52_RS04835 (OHM52_04835) 963434..963691 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM52_RS04840 (OHM52_04840) 963681..963920 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
OHM52_RS04845 (OHM52_04845) 964012..965983 - 1972 Protein_922 FtsX-like permease family protein -
OHM52_RS04850 (OHM52_04850) 965984..966736 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
OHM52_RS04855 (OHM52_04855) 966872..967606 - 735 WP_011922410.1 ABC transporter permease -
OHM52_RS04860 (OHM52_04860) 967608..968354 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 909534..984080 74546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T262453 WP_002935012.1 NZ_CP109937:c963691-963434 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT262453 WP_002935014.1 NZ_CP109937:c963920-963681 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References