Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 723868..725419 Replicon chromosome
Accession NZ_CP109937
Organism Streptococcus suis strain TRG6

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OHM52_RS03605 Protein ID WP_079739431.1
Coordinates 724142..725419 (+) Length 426 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OHM52_RS03600 Protein ID WP_000301765.1
Coordinates 723868..724140 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM52_RS03565 (OHM52_03565) 720071..720388 + 318 WP_053866439.1 hypothetical protein -
OHM52_RS03570 (OHM52_03570) 720740..721081 + 342 Protein_670 recombinase family protein -
OHM52_RS03575 (OHM52_03575) 721157..721252 + 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
OHM52_RS03580 (OHM52_03580) 721377..722114 + 738 WP_012477196.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OHM52_RS03585 (OHM52_03585) 722284..722544 + 261 Protein_673 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
OHM52_RS03590 (OHM52_03590) 722647..723543 + 897 WP_002334978.1 AAA family ATPase -
OHM52_RS03595 (OHM52_03595) 723642..723851 + 210 WP_000527318.1 peptide-binding protein -
OHM52_RS03600 (OHM52_03600) 723868..724140 + 273 WP_000301765.1 antitoxin Antitoxin
OHM52_RS03605 (OHM52_03605) 724142..725419 + 1278 WP_079739431.1 zeta toxin family protein Toxin
OHM52_RS03610 (OHM52_03610) 725506..726303 + 798 WP_053866438.1 AAA family ATPase -
OHM52_RS03615 (OHM52_03615) 726350..726565 + 216 WP_053866437.1 hypothetical protein -
OHM52_RS03620 (OHM52_03620) 726739..728088 + 1350 WP_053866436.1 ISLre2 family transposase -
OHM52_RS03625 (OHM52_03625) 728474..728749 + 276 WP_002936247.1 HU family DNA-binding protein -
OHM52_RS03630 (OHM52_03630) 728910..729122 + 213 WP_264516786.1 hypothetical protein -
OHM52_RS03635 (OHM52_03635) 729322..729789 + 468 WP_043033030.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage erm(B) - 720740..728749 8009


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 48802.57 Da        Isoelectric Point: 9.0764

>T262452 WP_079739431.1 NZ_CP109937:724142-725419 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Download         Length: 1278 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT262452 WP_000301765.1 NZ_CP109937:723868-724140 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References