262451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2853583..2854097 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag NT398_RS14280 Protein ID WP_001078344.1
Coordinates 2853771..2854097 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag NT398_RS14275 Protein ID WP_223200634.1
Coordinates 2853583..2853768 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS14240 (2848805) 2848805..2849089 + 285 WP_000917289.1 co-chaperone GroES -
NT398_RS14245 (2849165) 2849165..2850781 + 1617 WP_000240642.1 chaperonin GroEL -
NT398_RS14250 (2850850) 2850850..2852022 - 1173 WP_000179343.1 tyrosine-type recombinase/integrase -
NT398_RS14255 (2852036) 2852036..2852710 - 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
NT398_RS14260 (2852883) 2852883..2853101 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
NT398_RS14265 (2853106) 2853106..2853423 + 318 WP_000481967.1 helix-turn-helix domain-containing protein -
NT398_RS14270 (2853420) 2853420..2853566 + 147 WP_000784885.1 hypothetical protein -
NT398_RS14275 (2853583) 2853583..2853768 + 186 WP_223200634.1 pathogenicity island protein Antitoxin
NT398_RS14280 (2853771) 2853771..2854097 + 327 WP_001078344.1 DUF1474 family protein Toxin
NT398_RS14285 (2854162) 2854162..2855031 + 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
NT398_RS14290 (2855045) 2855045..2856754 + 1710 WP_000447473.1 DUF927 domain-containing protein -
NT398_RS14295 (2857064) 2857064..2857444 + 381 WP_000356942.1 hypothetical protein -
NT398_RS14300 (2857441) 2857441..2858082 + 642 WP_001047698.1 hypothetical protein -
NT398_RS14305 (2858532) 2858532..2858873 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / tsst-1 / sec / sell / hlb 2848805..2890893 42088


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T262451 WP_001078344.1 NZ_CP109933:2853771-2854097 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 7233.15 Da        Isoelectric Point: 4.4184

>AT262451 WP_223200634.1 NZ_CP109933:2853583-2853768 [Staphylococcus aureus]
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure

References