Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2801500..2802029 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NT398_RS14010 Protein ID WP_000621175.1
Coordinates 2801667..2802029 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NT398_RS14005 Protein ID WP_000948331.1
Coordinates 2801500..2801670 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS13975 (2796537) 2796537..2797097 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
NT398_RS13980 (2797305) 2797305..2797784 + 480 WP_001287087.1 hypothetical protein -
NT398_RS13985 (2797777) 2797777..2799360 + 1584 WP_001294626.1 PH domain-containing protein -
NT398_RS13990 (2799347) 2799347..2799838 + 492 WP_001205912.1 PH domain-containing protein -
NT398_RS13995 (2799842) 2799842..2800201 + 360 WP_000581197.1 holo-ACP synthase -
NT398_RS14000 (2800267) 2800267..2801415 + 1149 WP_001281154.1 alanine racemase -
NT398_RS14005 (2801500) 2801500..2801670 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NT398_RS14010 (2801667) 2801667..2802029 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NT398_RS14015 (2802379) 2802379..2803380 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NT398_RS14020 (2803499) 2803499..2803825 + 327 WP_001052491.1 anti-sigma factor antagonist -
NT398_RS14025 (2803827) 2803827..2804306 + 480 WP_001190829.1 anti-sigma B factor RsbW -
NT398_RS14030 (2804281) 2804281..2805051 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T262450 WP_000621175.1 NZ_CP109933:2801667-2802029 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT262450 WP_000948331.1 NZ_CP109933:2801500-2801670 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References