Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2781776..2782290 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NT398_RS13920 Protein ID WP_000581792.1
Coordinates 2782081..2782290 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NT398_RS13915 Protein ID WP_000138932.1
Coordinates 2781776..2782069 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS13895 (2776939) 2776939..2777580 + 642 WP_000483153.1 thiamine phosphate synthase -
NT398_RS13900 (2777666) 2777666..2778538 + 873 WP_000725802.1 membrane protein insertase YidC -
NT398_RS13905 (2779451) 2779451..2780098 - 648 WP_001187630.1 HD domain-containing protein -
NT398_RS13910 (2780126) 2780126..2781610 - 1485 WP_000571549.1 cardiolipin synthase -
NT398_RS13915 (2781776) 2781776..2782069 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NT398_RS13920 (2782081) 2782081..2782290 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NT398_RS13925 (2782418) 2782418..2782555 + 138 WP_000828354.1 Lmo0850 family protein -
NT398_RS13930 (2782819) 2782819..2784021 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NT398_RS13935 (2784339) 2784339..2785409 + 1071 WP_042109557.1 D-alanine--D-alanine ligase -
NT398_RS13940 (2785424) 2785424..2786782 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T262449 WP_000581792.1 NZ_CP109933:2782081-2782290 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT262449 WP_000138932.1 NZ_CP109933:2781776-2782069 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FF1


Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References