262443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2409954..2410477 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag NT398_RS11985 Protein ID WP_000074049.1
Coordinates 2410211..2410477 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NT398_RS11980 Protein ID WP_000587616.1
Coordinates 2409954..2410211 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS11965 (2406451) 2406451..2407200 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
NT398_RS11970 (2407395) 2407395..2408972 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NT398_RS11975 (2409140) 2409140..2409595 - 456 WP_000732076.1 DUF1307 domain-containing protein -
NT398_RS11980 (2409954) 2409954..2410211 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NT398_RS11985 (2410211) 2410211..2410477 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
NT398_RS11990 (2410832) 2410832..2411908 + 1077 WP_001076673.1 M42 family metallopeptidase -
NT398_RS11995 (2412156) 2412156..2412818 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NT398_RS12000 (2412811) 2412811..2413587 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
NT398_RS12005 (2413983) 2413983..2415170 + 1188 WP_063653202.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T262443 WP_000074049.1 NZ_CP109933:2410211-2410477 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT262443 WP_000587616.1 NZ_CP109933:2409954-2410211 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References