Detailed information of TA system TA026244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1200581..1201192
• Accession: NC_017068
• Organism: Selenomonas ruminantium subsp. lactilytica TAM6421

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0GPX1
• Locus tag: SELR_RS05650
• Protein ID: WP_014424245.1
• Coordinates: 1200581..1200763 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0GPX2
• Locus tag: SELR_RS05655
• Protein ID: WP_014424246.1
• Coordinates: 1200794..1201192 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELR_RS05630	1195733..1196362	+	630	WP_014424241.1	epoxyqueuosine reductase QueH	-
SELR_RS05635	1196359..1197534	+	1176	WP_014424242.1	SpoIID/LytB domain-containing protein	-
SELR_RS05640	1197551..1198645	+	1095	WP_014424243.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
SELR_RS05645	1198693..1200393	-	1701	WP_014424244.1	recombinase family protein	-
SELR_RS05650	1200581..1200763	+	183	WP_014424245.1	type II toxin-antitoxin system HicA family toxin	Toxin
SELR_RS05655	1200794..1201192	+	399	WP_014424246.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SELR_RS05660	1202233..1203069	-	837	WP_014424247.1	hypothetical protein	-
SELR_RS17650	1203166..1203576	-	411	WP_014424248.1	helix-turn-helix domain-containing protein	-
SELR_RS05670	1203720..1203929	+	210	WP_050992742.1	helix-turn-helix domain-containing protein	-
SELR_RS05675	1204073..1205050	-	978	WP_014424249.1	hypothetical protein	-
SELR_RS18275	1205209..1205445	+	237	WP_080585423.1	helix-turn-helix domain-containing protein	-
SELR_RS05680	1205417..1205599	+	183	WP_014424250.1	hypothetical protein	-
SELR_RS05685	1205764..1206033	+	270	WP_014424251.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1198693..1236760	38067

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-121)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6833.14 Da
• Isoelectric Point: 11.0775

>T26244 WP_014424245.1 NC_017068:1200581-1200763 [Selenomonas ruminantium subsp. lactilytica TAM6421]
MKPKDLLKILEADGWQVERIRGSHHILKHPTKPGRPVIPMHNKDMKPGTFNSILKQAGIK

Nucleotide

• Length: 183 bp

>T26244 NC_017068:1200581-1200763 [Selenomonas ruminantium subsp. lactilytica TAM6421]
ATGAAGCCAAAGGACTTACTAAAAATCCTTGAAGCGGATGGGTGGCAGGTTGAACGGATACGAGGCTCACATCATATCCT
AAAGCACCCGACAAAGCCGGGACGGCCCGTTATCCCAATGCATAACAAGGACATGAAGCCGGGAACATTCAACAGTATTT
TGAAGCAGGCAGGGATCAAATAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.55 Da
• Isoelectric Point: 4.2380

>AT26244 WP_014424246.1 NC_017068:1200794-1201192 [Selenomonas ruminantium subsp. lactilytica TAM6421]
MGKIFYPAVFHPEDDGGYSVDFPDLLGCVTEGDTLEEAMAMAEDALGIYLYTLKEDKEEASAPSSPADIKVGGRDFVTLI
EYDEVAYLKRTDSHAVKKTLTIPAWMDVLAKEHNLNFSNVLQNAIRRELNLA

Nucleotide

• Length: 399 bp

>AT26244 NC_017068:1200794-1201192 [Selenomonas ruminantium subsp. lactilytica TAM6421]
ATGGGAAAAATTTTTTATCCAGCAGTATTTCATCCGGAAGATGATGGTGGCTATTCTGTCGACTTCCCAGATTTGTTGGG
GTGCGTGACGGAAGGAGACACGCTGGAGGAAGCCATGGCCATGGCAGAGGACGCTTTGGGCATCTATCTTTATACGCTCA
AAGAGGACAAGGAAGAAGCTTCGGCTCCTTCTAGCCCAGCAGACATCAAGGTAGGCGGCCGCGATTTCGTGACGCTCATA
GAATATGATGAGGTTGCCTATCTGAAGCGTACAGACAGTCATGCCGTGAAAAAGACTTTGACCATACCAGCATGGATGGA
TGTGTTGGCCAAAGAGCATAATTTGAACTTTTCAAATGTCTTGCAGAACGCCATTCGTAGAGAATTAAATTTAGCTTGA

Structures

Toxin

• AlphaFold DB: I0GPX1

Antitoxin

• AlphaFold DB: I0GPX2