262435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 121587..122363 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NT398_RS00785 Protein ID WP_000031108.1
Coordinates 122211..122363 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NT398_RS00780 Protein ID WP_001251224.1
Coordinates 121587..122186 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS00760 (117503) 117503..118960 + 1458 WP_000649908.1 ABC transporter permease subunit -
NT398_RS00765 (118953) 118953..119675 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NT398_RS00770 (119826) 119826..120953 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NT398_RS00775 (120958) 120958..121428 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NT398_RS00780 (121587) 121587..122186 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NT398_RS00785 (122211) 122211..122363 + 153 WP_000031108.1 SAS053 family protein Toxin
NT398_RS00790 (122911) 122911..123306 + 396 WP_000901023.1 hypothetical protein -
NT398_RS00795 (123502) 123502..124887 + 1386 WP_000116228.1 class II fumarate hydratase -
NT398_RS00800 (125340) 125340..126161 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T262435 WP_000031108.1 NZ_CP109933:122211-122363 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT262435 WP_001251224.1 NZ_CP109933:121587-122186 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References