262431

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5736219..5736827 Replicon chromosome
Accession NZ_CP109932
Organism Pseudomonas aeruginosa strain PALA43

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag PALA43_RS26630 Protein ID WP_003114156.1
Coordinates 5736219..5736566 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA43_RS26635 Protein ID WP_003114155.1
Coordinates 5736576..5736827 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA43_RS26600 (PALA43_05290) 5731578..5731850 + 273 WP_073651557.1 cysteine-rich CWC family protein -
PALA43_RS26605 (PALA43_05291) 5731850..5732542 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
PALA43_RS26610 (PALA43_05292) 5732678..5733721 + 1044 WP_003098363.1 L,D-transpeptidase -
PALA43_RS26615 (PALA43_05293) 5733801..5734538 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PALA43_RS26620 (PALA43_05294) 5734990..5735892 + 903 WP_269972389.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA43_RS26630 (PALA43_05296) 5736219..5736566 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA43_RS26635 5736576..5736827 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA43_RS26640 (PALA43_05297) 5737041..5738024 - 984 WP_043154346.1 tyrosine-type recombinase/integrase -
PALA43_RS26645 (PALA43_05298) 5738024..5739316 - 1293 WP_269972390.1 hypothetical protein -
PALA43_RS26650 (PALA43_05300) 5739546..5740820 - 1275 WP_023093544.1 zonular occludens toxin family protein -
PALA43_RS26655 (PALA43_05301) 5740824..5741180 - 357 WP_152372558.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5736219..5757482 21263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T262431 WP_003114156.1 NZ_CP109932:c5736566-5736219 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT262431 WP_003114155.1 NZ_CP109932:c5736827-5736576 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References