262430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5416362..5417620 Replicon chromosome
Accession NZ_CP109932
Organism Pseudomonas aeruginosa strain PALA43

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA43_RS25045 Protein ID WP_269972378.1
Coordinates 5416362..5417117 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA43_RS25050 Protein ID WP_003086329.1
Coordinates 5417252..5417620 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA43_RS25035 (PALA43_04979) 5411534..5414077 + 2544 WP_021205057.1 acyl-homoserine-lactone acylase QuiP -
PALA43_RS25040 (PALA43_04980) 5414232..5415593 - 1362 WP_073657578.1 DNA recombination protein RmuC -
PALA43_RS25045 (PALA43_04981) 5416362..5417117 - 756 WP_269972378.1 RES family NAD+ phosphorylase Toxin
PALA43_RS25050 (PALA43_04982) 5417252..5417620 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA43_RS25055 (PALA43_04983) 5417693..5418979 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA43_RS25060 (PALA43_04984) 5419035..5420624 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA43_RS25065 (PALA43_04985) 5420703..5421179 + 477 WP_003112531.1 hypothetical protein -
PALA43_RS25070 5421182..5421457 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28196.34 Da        Isoelectric Point: 8.0554

>T262430 WP_269972378.1 NZ_CP109932:c5417117-5416362 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAGPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262430 WP_003086329.1 NZ_CP109932:c5417620-5417252 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References