Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4486227..4487448 Replicon chromosome
Accession NZ_CP109932
Organism Pseudomonas aeruginosa strain PALA43

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PALA43_RS20695 Protein ID WP_003114949.1
Coordinates 4486870..4487448 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA43_RS20690 Protein ID WP_003088112.1
Coordinates 4486227..4486781 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA43_RS20670 (PALA43_04107) 4481839..4482276 - 438 WP_003107652.1 cytochrome c-550 PedF -
PALA43_RS20675 (PALA43_04108) 4482589..4483458 + 870 Protein_4080 quinoprotein ethanol dehydrogenase -
PALA43_RS20680 4483465..4483869 + 405 WP_134593031.1 (2Fe-2S)-binding protein -
PALA43_RS20685 (PALA43_04109) 4483874..4486069 + 2196 WP_269972328.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA43_RS20690 (PALA43_04110) 4486227..4486781 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA43_RS20695 (PALA43_04111) 4486870..4487448 + 579 WP_003114949.1 HD domain-containing protein Toxin
PALA43_RS20700 (PALA43_04112) 4487556..4488743 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA43_RS20705 (PALA43_04113) 4488733..4490904 - 2172 WP_042930112.1 type I secretion system permease/ATPase -
PALA43_RS20710 (PALA43_04114) 4490894..4492171 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T262429 WP_003114949.1 NZ_CP109932:4486870-4487448 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262429 WP_003088112.1 NZ_CP109932:4486227-4486781 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References