Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Acetyltransf_4(toxin) |
| Location | 2937463..2938971 | Replicon | chromosome |
| Accession | NZ_CP109932 | ||
| Organism | Pseudomonas aeruginosa strain PALA43 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9HYX1 |
| Locus tag | PALA43_RS13705 | Protein ID | WP_003119682.1 |
| Coordinates | 2937463..2938050 (+) | Length | 196 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | PALA43_RS13710 | Protein ID | WP_023085439.1 |
| Coordinates | 2938117..2938971 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA43_RS13700 (PALA43_02719) | 2933718..2937197 | - | 3480 | WP_003117605.1 | PAS domain-containing hybrid sensor histidine kinase/response regulator | - |
| PALA43_RS13705 (PALA43_02720) | 2937463..2938050 | + | 588 | WP_003119682.1 | GNAT family protein | Toxin |
| PALA43_RS13710 (PALA43_02721) | 2938117..2938971 | + | 855 | WP_023085439.1 | AraC family transcriptional regulator | Antitoxin |
| PALA43_RS13715 (PALA43_02722) | 2939068..2941233 | + | 2166 | WP_003115567.1 | TonB-dependent receptor family protein | - |
| PALA43_RS13720 (PALA43_02723) | 2941408..2943282 | + | 1875 | WP_003117607.1 | MFS transporter | - |
| PALA43_RS13725 (PALA43_02724) | 2943343..2943552 | - | 210 | WP_003115568.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21901.23 Da Isoelectric Point: 9.8676
>T262428 WP_003119682.1 NZ_CP109932:2937463-2938050 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
Download Length: 588 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31887.20 Da Isoelectric Point: 7.5295
>AT262428 WP_023085439.1 NZ_CP109932:2938117-2938971 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALGLGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALGLGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|