Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1702656..1703293 Replicon chromosome
Accession NZ_CP109932
Organism Pseudomonas aeruginosa strain PALA43

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PALA43_RS07880 Protein ID WP_019725766.1
Coordinates 1702656..1702838 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PALA43_RS07885 Protein ID WP_019725767.1
Coordinates 1702871..1703293 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA43_RS07860 1699639..1699782 + 144 WP_153274318.1 hypothetical protein -
PALA43_RS07865 (PALA43_01566) 1700108..1700443 - 336 WP_269972481.1 nuclease-related domain-containing protein -
PALA43_RS07870 (PALA43_01567) 1700536..1701657 - 1122 WP_080911355.1 Fic family protein -
PALA43_RS07875 1701916..1702053 - 138 WP_003113217.1 hypothetical protein -
PALA43_RS07880 (PALA43_01568) 1702656..1702838 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
PALA43_RS07885 (PALA43_01569) 1702871..1703293 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PALA43_RS07890 (PALA43_01571) 1703539..1704510 - 972 WP_025982283.1 hypothetical protein -
PALA43_RS07895 (PALA43_01572) 1704495..1705187 - 693 WP_019725770.1 hypothetical protein -
PALA43_RS07900 (PALA43_01573) 1705184..1705726 - 543 WP_025982284.1 hypothetical protein -
PALA43_RS07905 (PALA43_01574) 1705723..1706646 - 924 WP_019725772.1 hypothetical protein -
PALA43_RS07910 (PALA43_01575) 1706643..1707119 - 477 WP_019725773.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1700536..1753874 53338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T262427 WP_019725766.1 NZ_CP109932:1702656-1702838 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT262427 WP_019725767.1 NZ_CP109932:1702871-1703293 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References