Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5052580..5054088 Replicon chromosome
Accession NZ_CP109931
Organism Pseudomonas aeruginosa strain PALA42

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA42_RS23645 Protein ID WP_003119682.1
Coordinates 5053501..5054088 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7M2ZM82
Locus tag PALA42_RS23640 Protein ID WP_023087137.1
Coordinates 5052580..5053434 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA42_RS23625 (PALA42_04676) 5047999..5048208 + 210 WP_003115568.1 cold-shock protein -
PALA42_RS23630 (PALA42_04677) 5048269..5050143 - 1875 WP_003117607.1 MFS transporter -
PALA42_RS23635 (PALA42_04678) 5050318..5052483 - 2166 WP_009876821.1 TonB-dependent receptor family protein -
PALA42_RS23640 (PALA42_04679) 5052580..5053434 - 855 WP_023087137.1 AraC family transcriptional regulator Antitoxin
PALA42_RS23645 (PALA42_04680) 5053501..5054088 - 588 WP_003119682.1 GNAT family protein Toxin
PALA42_RS23650 (PALA42_04681) 5054354..5057833 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262424 WP_003119682.1 NZ_CP109931:c5054088-5053501 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31925.22 Da        Isoelectric Point: 7.5295

>AT262424 WP_023087137.1 NZ_CP109931:c5053434-5052580 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHSGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2ZM82

References