Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3403672..3404893 Replicon chromosome
Accession NZ_CP109931
Organism Pseudomonas aeruginosa strain PALA42

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA42_RS16015 Protein ID WP_003102740.1
Coordinates 3403672..3404250 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA42_RS16020 Protein ID WP_003088112.1
Coordinates 3404339..3404893 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA42_RS16000 (PALA42_03167) 3398948..3400225 + 1278 WP_003160086.1 TolC family protein -
PALA42_RS16005 (PALA42_03168) 3400215..3402386 + 2172 WP_070654195.1 type I secretion system permease/ATPase -
PALA42_RS16010 (PALA42_03169) 3402376..3403563 + 1188 WP_061189744.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA42_RS16015 (PALA42_03170) 3403672..3404250 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA42_RS16020 (PALA42_03171) 3404339..3404893 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA42_RS16025 (PALA42_03172) 3405051..3407246 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA42_RS16030 (PALA42_03173) 3407251..3407712 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA42_RS16035 (PALA42_03174) 3408043..3408366 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA42_RS16040 (PALA42_03175) 3408379..3408777 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA42_RS16045 (PALA42_03176) 3408774..3409325 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262423 WP_003102740.1 NZ_CP109931:c3404250-3403672 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262423 WP_003088112.1 NZ_CP109931:c3404893-3404339 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References