Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2487228..2488486 Replicon chromosome
Accession NZ_CP109931
Organism Pseudomonas aeruginosa strain PALA42

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA42_RS11730 Protein ID WP_003112528.1
Coordinates 2487731..2488486 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA42_RS11725 Protein ID WP_003086329.1
Coordinates 2487228..2487596 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA42_RS11705 2483391..2483666 + 276 WP_023088486.1 zinc ribbon domain-containing protein -
PALA42_RS11710 (PALA42_02310) 2483669..2484145 - 477 WP_004353334.1 elongation factor GreAB -
PALA42_RS11715 (PALA42_02311) 2484224..2485813 + 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PALA42_RS11720 (PALA42_02312) 2485869..2487155 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA42_RS11725 (PALA42_02313) 2487228..2487596 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA42_RS11730 (PALA42_02314) 2487731..2488486 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA42_RS11735 (PALA42_02315) 2489255..2490616 + 1362 WP_073652223.1 DNA recombination protein RmuC -
PALA42_RS11740 (PALA42_02316) 2490771..2493314 - 2544 WP_070654225.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T262422 WP_003112528.1 NZ_CP109931:2487731-2488486 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262422 WP_003086329.1 NZ_CP109931:2487228-2487596 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References