262421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2421677..2422317 Replicon chromosome
Accession NZ_CP109931
Organism Pseudomonas aeruginosa strain PALA42

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PALA42_RS11365 Protein ID WP_033993319.1
Coordinates 2421907..2422317 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA42_RS11360 Protein ID WP_031634724.1
Coordinates 2421677..2421907 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA42_RS11350 (PALA42_02242) 2418679..2419431 - 753 WP_121372664.1 hypothetical protein -
PALA42_RS11355 (PALA42_02243) 2419440..2421359 - 1920 WP_121372663.1 type I DNA topoisomerase -
PALA42_RS11360 2421677..2421907 + 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PALA42_RS11365 (PALA42_02244) 2421907..2422317 + 411 WP_033993319.1 tRNA(fMet)-specific endonuclease VapC Toxin
PALA42_RS11370 (PALA42_02245) 2422333..2422530 + 198 WP_003123325.1 hypothetical protein -
PALA42_RS11375 (PALA42_02246) 2422544..2422762 + 219 WP_121372662.1 hypothetical protein -
PALA42_RS11380 2422828..2423025 - 198 WP_071536305.1 CrpP family ICE-associated protein -
PALA42_RS11385 (PALA42_02247) 2423525..2424013 - 489 WP_121372661.1 single-stranded DNA-binding protein -
PALA42_RS11390 (PALA42_02248) 2424027..2424557 - 531 WP_121372660.1 DUF3158 family protein -
PALA42_RS11395 (PALA42_02249) 2424563..2425291 - 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
PALA42_RS11400 (PALA42_02250) 2425448..2425618 - 171 WP_231786506.1 hypothetical protein -
PALA42_RS11405 (PALA42_02251) 2425958..2427283 - 1326 WP_121372659.1 STY4528 family pathogenicity island replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15422.76 Da        Isoelectric Point: 7.3233

>T262421 WP_033993319.1 NZ_CP109931:2421907-2422317 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVAPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT262421 WP_031634724.1 NZ_CP109931:2421677-2421907 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References